The complete genome of a baculovirus isolated from an insect of medical interest: Lonomia obliqua (Lepidoptera: Saturniidae)

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dc.contributor.authorAragao-Silva C.W.
dc.contributor.authorAndrade M.S.
dc.contributor.authorArdisson-Araujo D.M.P.
dc.contributor.authorFernandes J.E.A.
dc.contributor.authorMorgado F.S.
dc.contributor.authorBao S.N.
dc.contributor.authorMoraes R.H.P.
dc.contributor.authorWolff J.L.C.
dc.contributor.authorMelo F.L.
dc.contributor.authorRibeiro B.M.
dc.date.accessioned2024-03-13T00:53:02Z
dc.date.available2024-03-13T00:53:02Z
dc.date.issued2016
dc.description.abstractLonomia obliqua (Lepidoptera: Saturniidae) is a species of medical importance due to the severity of reactions caused by accidental contact with the caterpillar bristles. Several natural pathogens have been identified in L. obliqua, and among them the baculovirus Lonomia obliqua multiple nucleopolyhedrovirus (LoobMNPV). The complete genome of LoobMNPV was sequenced and shown to have 120,022 bp long with 134 putative open reading frames (ORFs). Phylogenetic analysis of the LoobMNPV genome showed that it belongs to Alphabaculovirus group I (lepidopteran-infective NPV). A total of 12 unique ORFs were identified with no homologs in other sequenced baculovirus genomes. One of these, the predicted protein encoded by loob035, showed significant identity to an eukaryotic transcription terminator factor (TTF2) from the Lepidoptera Danaus plexippus, suggesting an independent acquisition through horizontal gene transfer. Homologs of cathepsin and chitinase genes, which are involved in host integument liquefaction and viral spread, were not found in this genome. As L. obliqua presents a gregarious behavior during the larvae stage the impact of this deletion might be neglectable.
dc.description.volume6
dc.identifier.doi10.1038/srep23127
dc.identifier.issn2045-2322
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/35963
dc.relation.ispartofScientific Reports
dc.rightsAcesso Aberto
dc.titleThe complete genome of a baculovirus isolated from an insect of medical interest: Lonomia obliqua (Lepidoptera: Saturniidae)
dc.typeArtigo
local.scopus.citations10
local.scopus.eid2-s2.0-84973662257
local.scopus.subjectAnimals
local.scopus.subjectBase Sequence
local.scopus.subjectDNA, Viral
local.scopus.subjectGene Transfer, Horizontal
local.scopus.subjectGenome, Viral
local.scopus.subjectInsect Proteins
local.scopus.subjectLarva
local.scopus.subjectMoths
local.scopus.subjectNucleopolyhedrovirus
local.scopus.subjectOpen Reading Frames
local.scopus.subjectPhylogeny
local.scopus.subjectSequence Alignment
local.scopus.subjectSequence Analysis, DNA
local.scopus.subjectTrans-Activators
local.scopus.subjectTranscription Factors
local.scopus.updated2024-05-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84973662257&origin=inward
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