Heart rate variability is a trait marker of major depressive disorder: Evidence from the sertraline vs electric current therapy to treat depression clinical study

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dc.contributor.authorBrunoni A.R.
dc.contributor.authorKemp A.H.
dc.contributor.authorDantas E.M.
dc.contributor.authorGoulart A.C.
dc.contributor.authorNunes M.A.
dc.contributor.authorBoggio P.S.
dc.contributor.authorMill J.G.
dc.contributor.authorLotufo P.A.
dc.contributor.authorFregni F.
dc.contributor.authorBensenor I.M.
dc.date.accessioned2024-03-13T01:03:46Z
dc.date.available2024-03-13T01:03:46Z
dc.date.issued2013
dc.description.abstractDecreased heart rate variability (HRV) is a cardiovascular predictor of mortality. Recent debate has focused on whether reductions in HRV in major depressive disorder (MDD) are a consequence of the disorder or a consequence of pharmacotherapy. Here we report on the impact of transcranial direct current stimulation (tDCS), a non-pharmacological intervention, vs sertraline to further investigate this issue. The employed design was a double-blind, randomized, factorial, placebo-controlled trial. One hundred and eighteen moderate-To-severe, medication-free, low-cardiovascular risk depressed patients were recruited for this study and allocated to either active/sham tDCS (10 consecutive sessions plus two extra sessions every other week) or placebo/sertraline (50Â mg/d) for 6Â wk. Patients were age and gender-matched to healthy controls from a concurrent cohort study [the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)]. The impact of disorder, treatment and clinical response on HRV (root mean square of successive differences and high frequency) was examined. Our findings confirmed that patients displayed decreased HRV relative to controls. Furthermore, HRV scores did not change following treatment with either a non-pharmacological (tDCS) or pharmacological (sertraline) intervention, nor did HRV increase with clinical response to treatment. Based on these findings, we discuss whether reduced HRV is a trait-marker for MDD, which may predispose patients to a host of conditions and disease even after response to treatment. Our findings have important implications for our understanding of depression pathophysiology and the relationship between MDD, cardiovascular disorders and mortality. © © CINP 2013Â.
dc.description.firstpage1937
dc.description.issuenumber9
dc.description.lastpage1949
dc.description.volume16
dc.identifier.doi10.1017/S1461145713000497
dc.identifier.issn1469-5111
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/36565
dc.relation.ispartofInternational Journal of Neuropsychopharmacology
dc.rightsAcesso Aberto
dc.subject.otherlanguageHeart rate variability
dc.subject.otherlanguagemajor depressive disorder
dc.subject.otherlanguagerandomized controlled trial
dc.subject.otherlanguageserotonin uptake inhibitors
dc.subject.otherlanguagesertraline
dc.subject.otherlanguagetranscranial direct current stimulation
dc.titleHeart rate variability is a trait marker of major depressive disorder: Evidence from the sertraline vs electric current therapy to treat depression clinical study
dc.typeArtigo
local.scopus.citations117
local.scopus.eid2-s2.0-84883402655
local.scopus.updated2024-05-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84883402655&origin=inward
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