N-doped graphene quantum dots combined with Ag nanoparticles for luminescence based analytical sensing of gentamycin after solid-phase extraction in a molecularly-imprinted polymer

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dc.contributor.authorPinto I.A.
dc.contributor.authorToloza C.A.T.
dc.contributor.authorDe Falco A.
dc.contributor.authorAlmeida J.M.S.
dc.contributor.authorPedrozo-Penafiel M.J.
dc.contributor.authorda Silva A.R.
dc.contributor.authorLarrude D.G.
dc.contributor.authorAucelio R.Q.
dc.date.accessioned2025-04-01T06:17:35Z
dc.date.available2025-04-01T06:17:35Z
dc.date.issued2025
dc.description.abstract© 2025 Elsevier B.V.A luminescence-based method was developed to detect gentamicin using silver nanoparticles (AgNPs) associated with nitrogen-doped graphene quantum dots (N-GQDs). When gentamicin sulfate interacts with the AgNPs/N-GQDs system, the characteristic blue fluorescence of N-GQDs, which had been previously turned off by AgNPs, is restored. Under specific conditions (such as the amount of synthesis dispersion and pH), this AgNPs/N-GQDs probe enabled quantification of gentamicin ranging from 3.0 × 10−7 to 6.0 × 10−6 mol L−1. To address interference from other substances during the analysis, a solid-phase extraction, with a kanamycin-imprinted polymer cartridge, enabled accurate results. Two veterinary pharmaceutical samples were used to test the method and results were in agreement with those achieved by obtained using high-performance liquid chromatography with analyte chemical derivatization. This new method is straightforward, sensitive, and selective, and it is also considered eco-friendly (0.63 score Analytical greenness calculator) since it avoids the use of toxic chemical derivatization reagents, use nanoquantities of carbon and silver based nanomaterials and aqueous systems.
dc.description.volume260
dc.identifier.doi10.1016/j.jpba.2025.116795
dc.identifier.issnNone
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/40325
dc.relation.ispartofJournal of Pharmaceutical and Biomedical Analysis
dc.rightsAcesso Restrito
dc.subject.otherlanguageGentamycin
dc.subject.otherlanguageGraphene quantum dots
dc.subject.otherlanguageMolecularly-imprinted polymer
dc.subject.otherlanguagePhotoluminescence
dc.subject.otherlanguageSilver nanoparticles
dc.titleN-doped graphene quantum dots combined with Ag nanoparticles for luminescence based analytical sensing of gentamycin after solid-phase extraction in a molecularly-imprinted polymer
dc.typeArtigo
local.scopus.citations0
local.scopus.eid2-s2.0-86000611020
local.scopus.updated2025-04-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=86000611020&origin=inward
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