Cytotoxicity evaluation of Curcuma zedoaria (Christm.) Roscoe fluid extract used in oral hygiene products

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dc.contributor.authorDos Santos Fernandes J.P.
dc.contributor.authorMello-Moura A.C.V.
dc.contributor.authorMarques M.M.
dc.contributor.authorNicoletti M.A.
dc.date.accessioned2024-03-13T01:06:56Z
dc.date.available2024-03-13T01:06:56Z
dc.date.issued2012
dc.description.abstractObjective: This in vitro study evaluated the cytotoxic effects of the Curcuma zedoaria (Christm.) Roscoe (popular name: zedoary) fluid extract, as used in preparations for oral hygiene, mostly for anti-septic purposes. Materials and methods: The cell viability and cell growth were assessed by Trypan blue dye exclusion assay using the LMF cell line derived from oral mucosa. Cell viability (short-term assay) was measured 0, 6, 12 and 24 h after contact with the fluid extract. Cell growth (long-term assay) was analyzed in 1, 3, 5 and 7 days. The experimental groups were those testing the fluid extract obtained from the zedoary rhizome and the extractor liquid (ethanol 70° GL) in the concentrations of 0.01-0.0001% v/v. Fresh DMEM were used in the control cultures. Results: Short-term assay - all studied cultures maintained stable cell viability; Longterm assay - there was progressive cell growth in all studied cultures. Conclusion: According to the results, the zedoary fluid extract presents low cytotoxicity and probably can be used in the oral hygiene products. © 2012 Informa Healthcare.
dc.description.firstpage610
dc.description.issuenumber6
dc.description.lastpage614
dc.description.volume70
dc.identifier.doi10.3109/00016357.2011.645060
dc.identifier.issn0001-6357
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/36744
dc.relation.ispartofActa Odontologica Scandinavica
dc.rightsAcesso Restrito
dc.subject.otherlanguageCell culture
dc.subject.otherlanguageCytotoxicity
dc.subject.otherlanguageVegetal extract
dc.subject.otherlanguageZedoary
dc.titleCytotoxicity evaluation of Curcuma zedoaria (Christm.) Roscoe fluid extract used in oral hygiene products
dc.typeArtigo
local.scopus.citations8
local.scopus.eid2-s2.0-84867292832
local.scopus.updated2024-05-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84867292832&origin=inward
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