Crescentic glomerulonephritis due to linear IgA anti-glomerular basement membrane disease: report of a rare case

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dc.contributor.authorMonich A.G.
dc.contributor.authorRomani R.F.
dc.contributor.authorCarneiro J.L.S.
dc.date.accessioned2024-09-01T06:17:18Z
dc.date.available2024-09-01T06:17:18Z
dc.date.issued2024
dc.description.abstract© 2024, Associacao Brasileira de Divulgacao Cientifica. All rights reserved.Anti-glomerular basement membrane (GBM) disease is a rare and severe vasculitis that affects the glomerular and pulmonary capillaries and has an incidence of less than 2 cases per million individuals per year. Anti-GBM disease is mediated by autoantibodies against the a3 chain of type IV collagen. In the majority of cases, the autoantibodies are of the immunoglobulin G (IgG) class, with rare cases being mediated by immunoglobulin M (IgM) or immunoglobulin A (IgA); there are less than 15 IgA-mediated cases reported in the literature worldwide. The classic form of this disease manifests with rapidly progressive glomerulonephritis (RPGN), with or without pulmonary hemorrhage, and the diagnosis consists of identifying high titers of autoantibodies in the serum and/or deposited in the tissues. IgA antibodies are not identified in routine immunoassay tests, and renal biopsy with immunofluorescence is essential for diagnosis. We present a case of RPGN due to anti-GBM disease with linear IgA deposition, whose diagnosis was made exclusively by renal biopsy and with an unfavorable prognosis.
dc.description.volume57
dc.identifier.doi10.1590/1414-431X2024e13466
dc.identifier.issnNone
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/39290
dc.relation.ispartofBrazilian Journal of Medical and Biological Research
dc.rightsAcesso Aberto
dc.subject.otherlanguageAnti-glomerular basement membrane disease
dc.subject.otherlanguageChronic
dc.subject.otherlanguageImmunoglobulin A
dc.subject.otherlanguageRenal insufficiency
dc.titleCrescentic glomerulonephritis due to linear IgA anti-glomerular basement membrane disease: report of a rare case
dc.typeArtigo
local.scopus.citations0
local.scopus.eid2-s2.0-85192639786
local.scopus.subjectAnti-Glomerular Basement Membrane Disease
local.scopus.subjectAutoantibodies
local.scopus.subjectBiopsy
local.scopus.subjectFemale
local.scopus.subjectGlomerulonephritis
local.scopus.subjectHumans
local.scopus.subjectImmunoglobulin A
local.scopus.subjectMale
local.scopus.updated2025-04-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85192639786&origin=inward
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