Solvent Screening Is Not Solvent Effect: A Review on the Most Neglected Aspect of Multicomponent Reactions

dc.contributor.authorNeto B.A.D.
dc.contributor.authorEberlin M.N.
dc.contributor.authorSherwood J.
dc.date.accessioned2024-03-12T19:14:18Z
dc.date.available2024-03-12T19:14:18Z
dc.date.issued2022
dc.description.abstract© 2022 Wiley-VCH GmbH.In the current Perspective article, we critically review and discuss the importance of solvent effects on multicomponent reactions, likely the most neglected aspect in this research field. Although solvent-free reactions may be desirable sometimes, most multicomponent reactions still require a solvent to properly promote them. This requirement makes the knowledge of all drawbacks and advantages of each solvent a central issue when trying to optimize multicomponent reactions. Yet, only a few studies with actual evidence of solvent effects on these key reactions have been published. For the quantitative effects of solvents, studies are even scarcer. In this Perspective, we argue that greater efforts should be directed to such fundamental studies.
dc.description.issuenumber30
dc.description.volume2022
dc.identifier.doi10.1002/ejoc.202200172
dc.identifier.issn1099-0690
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/34326
dc.relation.ispartofEuropean Journal of Organic Chemistry
dc.rightsAcesso Restrito
dc.subject.otherlanguageControl
dc.subject.otherlanguageMechanism
dc.subject.otherlanguageMulticomponent reactions
dc.subject.otherlanguageSolvent effect
dc.subject.otherlanguageSynthetic methods
dc.titleSolvent Screening Is Not Solvent Effect: A Review on the Most Neglected Aspect of Multicomponent Reactions
dc.typeArtigo
local.scopus.citations6
local.scopus.eid2-s2.0-85129938995
local.scopus.updated2024-06-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85129938995&origin=inward
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