A plug, print & play inkjet printing and impedance-based biosensing technology operating through a smartphone for clinical diagnostics

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dc.contributor.authorRosati G.
dc.contributor.authorUrban M.
dc.contributor.authorZhao L.
dc.contributor.authorYang Q.
dc.contributor.authorde Carvalho Castro e Silva C.
dc.contributor.authorBonaldo S.
dc.contributor.authorParolo C.
dc.contributor.authorNguyen E.P.
dc.contributor.authorOrtega G.
dc.contributor.authorFornasiero P.
dc.contributor.authorPaccagnella A.
dc.contributor.authorMerkoci A.
dc.date.accessioned2024-03-12T19:15:45Z
dc.date.available2024-03-12T19:15:45Z
dc.date.issued2022
dc.description.abstract© 2021Simplicity is one of the key feature for the spread of any successful technological product. Here, a method for rapid and low-cost fabrication of electrochemical biosensors is presented. This “plug, print & play” method involves inkjet-printing even in an office-like environment, without the need of highly specialized expertise or equipment, guaranteeing an ultra-fast idea to (scaled) prototype production time. The printed biosensors can be connected to a smartphone through its audio input for their impedance readout, demonstrating the validity of the system for point-of-care biosensing. Proper electrodes layout guarantees high sensitivity and is validated by finite element simulations. The introduction of a passivation method (wax printing) allowed to complete the devices fabrication process, increasing their sensitivity. Indeed, the wax allowed reducing the interference related to the parasitic currents flowing through the permeable coating of the employed substrates, which was used for the chemical sintering, thus avoiding the common thermal treatment after printing. As a case study, we used the devices to develop an electrochemical aptamer-based sensor for the rapid detection of neutrophil gelatinase-associated lipocalin (NGAL) in urine – a clinically important marker of acute kidney injury. The aptasensor platform is capable of detecting clinically relevant concentrations of NGAL with a simple and rapid smartphone readout. The developed technology may be extended in the future to continuous monitoring, taking advantage of its flexibility to integrate it in tubes, or to other diagnostic applications where cost/efficiency and rapidity of the research, development and implementation of point of care devices is a must.
dc.description.volume196
dc.identifier.doi10.1016/j.bios.2021.113737
dc.identifier.issn1873-4235
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/34405
dc.relation.ispartofBiosensors and Bioelectronics
dc.rightsAcesso Aberto
dc.subject.otherlanguageAptasensors
dc.subject.otherlanguageFlexible electronics
dc.subject.otherlanguageImpedimetric biosensors
dc.subject.otherlanguageInkjet-printed sensors
dc.subject.otherlanguageNanofunctional inks
dc.subject.otherlanguageSmartphone readout
dc.titleA plug, print & play inkjet printing and impedance-based biosensing technology operating through a smartphone for clinical diagnostics
dc.typeArtigo
local.scopus.citations41
local.scopus.eid2-s2.0-85118508371
local.scopus.subjectAptasensors
local.scopus.subjectBiosensing
local.scopus.subjectImpedimetric biosensors
local.scopus.subjectInk jet
local.scopus.subjectInk-jet printing
local.scopus.subjectInkjet-printed sensor
local.scopus.subjectNanofunctional ink
local.scopus.subjectPrinted sensors
local.scopus.subjectSmart phones
local.scopus.subjectSmartphone readout
local.scopus.subjectBiosensing Techniques
local.scopus.subjectElectric Impedance
local.scopus.subjectElectrodes
local.scopus.subjectSmartphone
local.scopus.subjectTechnology
local.scopus.updated2024-12-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85118508371&origin=inward
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