Is there a place for genetics in the management of PONV?
Tipo
Artigo de revisão
Data de publicação
2020
Periódico
Best Practice and Research: Clinical Anaesthesiology
Citações (Scopus)
8
Autores
Candiotti K.
Shrestha C.
Silva Ceschim M.R.
Shrestha C.
Silva Ceschim M.R.
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Título de Volume
Membros da banca
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Resumo
© 2020 Elsevier LtdAntiemetic prophylaxis for postoperative nausea and vomiting (PONV) – a frequent complication in the postoperative period – is routinely given to high-risk patients. However, standard PONV risk models do not account for genetic factors, which have been shown to have a significant influence on PONV incidence and drug response. In this review, we describe the polymorphisms of various genes (serotonin, dopamine, cholinergic, etc.) and how pharmacogenomics is involved in the pathophysiology of PONV. This review also addresses how genetics is involved in today's clinical practice related to PONV and how it will change in the upcoming years as personalized medicine advances.
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Assuntos Scopus
Antiemetics , Disease Management , Genetic Testing , Humans , Pharmacogenetics , Postoperative Nausea and Vomiting , Receptors, Dopamine , Receptors, Serotonin, 5-HT3 , Serotonin 5-HT3 Receptor Antagonists