Preventive role of exercise training in autonomic, hemodynamic, and metabolic parameters in rats under high risk of metabolic syndrome development

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dc.contributor.authorMoraes-Silva I.C.
dc.contributor.authorMostarda C.
dc.contributor.authorDias Moreira E.
dc.contributor.authorSilva K.A.S.
dc.contributor.authorDos Santos F.
dc.contributor.authorDe Angelis K.
dc.contributor.authorDe Moura Azevedo Farah V.
dc.contributor.authorIrigoyen M.C.
dc.date.accessioned2024-03-13T01:05:01Z
dc.date.available2024-03-13T01:05:01Z
dc.date.issued2013
dc.description.abstractHigh fructose consumption contributes to metabolic syndrome incidence, whereas exercise training promotes several beneficial adaptations. In this study, we demonstrated the preventive role of exercise training in the metabolic syndrome derangements in a rat model. Wistar rats receiving fructose overload in drinking water (100 g/l) were concomitantly trained on a treadmill (FT) or kept sedentary (F) for 10 wk. Control rats treated with normal water were also submitted to exercise training (CT) or sedentarism (C). Metabolic evaluations consisted of the Lee index and glycemia and insulin tolerance test (kITT). Blood pressure (BP) was directly measured, whereas heart rate (HR) and BP variabilities were evaluated in time and frequency domains. Renal sympathetic nerve activity was also recorded. F rats presented significant alterations compared with all the other groups in insulin resistance (in mg·dl -1·min-1: F: 3.4 ± 0.2; C: 4.7 ± 0.2; CT: 5.0 ± 0.5 FT: 4.6 ± 0.4), mean BP (in mmHG: F: 117 ± 2; C: 100 ± 2; CT: 98 ± 2; FT: 105 ± 2), and Lee index (in g/mm: F = 0.31 ± 0.001; C = 0.29 ± 0.001; CT = 0.27 ± 0.002; FT = 0.28 ± 0.002), confirming the metabolic syndrome diagnosis. Exercise training blunted all these derangements. Additionally, FS group presented autonomic dysfunction in relation to the others, as seen by an ∼50% decrease in baroreflex sensitivity and 24% in HR variability, and increases in sympathovagal balance (140%) and in renal sympathetic nerve activity (45%). These impairments were not observed in FT group, as well as in C and CT. Correlation analysis showed that both Lee index and kITT were associated with vagal impairment caused by fructose. Therefore, exercise training plays a preventive role in both autonomic and hemodynamic alterations related to the excessive fructose consumption. Copyright © 2013 the American Physiological Society.
dc.description.firstpage786
dc.description.issuenumber6
dc.description.lastpage791
dc.description.volume114
dc.identifier.doi10.1152/japplphysiol.00586.2012
dc.identifier.issn8750-7587
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/36636
dc.relation.ispartofJournal of Applied Physiology
dc.rightsAcesso Restrito
dc.subject.otherlanguageAutonomic nervous system
dc.subject.otherlanguageFructose; exercise training
dc.titlePreventive role of exercise training in autonomic, hemodynamic, and metabolic parameters in rats under high risk of metabolic syndrome development
dc.typeArtigo
local.scopus.citations49
local.scopus.eid2-s2.0-84878536550
local.scopus.updated2024-05-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84878536550&origin=inward
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