Carotid intima-media thickness in spondyloarthritis patients Espessamento da camada média-íntima da carótida em pacientes com espondiloartrite

Página do item simplificado
dc.contributor.authorLarocca Skare T.
dc.contributor.authorVerceze G.C.
dc.contributor.authorde Oliveira A.A.
dc.contributor.authorPerreto S.
dc.date.accessioned2024-03-13T01:06:17Z
dc.date.available2024-03-13T01:06:17Z
dc.date.issued2013
dc.description.abstractCONTEXT AND OBJECTIVE: Accelerated atherosclerosis has become a major problem in rheumatic inflammatory disease. The aim here was to analyze carotid intima-media thickness (IMT) in spondyloarthri-tis (SpA) patients and correlate this with clinical parameters and inflammatory markers. DESIGN AND SETTING: Cross-sectional analytical study at Rheumatology Outpatient Clinic, Evangelical University Hospital, Curitiba. METHODS: IMTs (measured using Doppler ultrasonography) of 36 SpA patients were compared with controls. The IMT in SpA patients was associated with inflammatory markers, like erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) and Bath Ankylosing Spondylitis Disease Activity Index (BASDAI); and with clinical parameters, like axial or peripheral involvement, dactylitis, HLA B27, uveitis occurrence, Bath Ankylosing Spondylitis Functional Index (BASFI) and lipid profile. RESULTS: The mean IMT in SpA patients was 0.72 ± 0.21 mm; in controls, 0.57 ± 0.13 mm (P = 0.0007). There were no associations with ESR, CRP, BASDAI or clinical data. In univariate analysis, greater IMT was seen in patients with longer disease duration (P = 0.014; Pearson R = 0.40; 95% confidence interval, CI = 0.06 to 0.65); higher triglycerides (P = 0.02; Spearman R = 0.37; 95% CI = 0.03 to 0.64); and older age (P = 0.0014; Pearson R 0.51; 95% CI = 0.21 to 0.72). CONCLUSION: SpA patients have a higher degree of subclinical atherosclerosis than in controls, thus supporting clinical evidence of increased cardiovascular risk in rheumatic patients.
dc.description.firstpage100
dc.description.issuenumber2
dc.description.lastpage105
dc.description.volume131
dc.identifier.doi10.1590/S1516-31802013000100020
dc.identifier.issn1516-3180
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/36707
dc.relation.ispartofSao Paulo Medical Journal
dc.rightsAcesso Aberto
dc.subject.otherlanguageAnkylosing
dc.subject.otherlanguageAtherosclerosis
dc.subject.otherlanguageCarotid artery diseases
dc.subject.otherlanguageInfammation
dc.subject.otherlanguageSpondylarthropathies
dc.subject.otherlanguageSpondylitis
dc.titleCarotid intima-media thickness in spondyloarthritis patients Espessamento da camada média-íntima da carótida em pacientes com espondiloartrite
dc.typeArtigo
local.scopus.citations17
local.scopus.eid2-s2.0-84876957447
local.scopus.updated2024-05-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84876957447&origin=inward
Arquivos
Coleções
Artigos de periódico