High Salt Intake Promotes Different Responses to Urodilatin and Uroguanylin in the Isolated Rat Kidney

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dc.contributor.authorJorge A.R.C.
dc.contributor.authorCosta P.H.S.
dc.contributor.authorMonteiro H.S.A.
dc.contributor.authorFonteles M.C.
dc.date.accessioned2024-03-12T23:58:29Z
dc.date.available2024-03-12T23:58:29Z
dc.date.issued2018
dc.description.abstract© Georg Thieme Verlag KG Stuttgart.New York.Urodilatin (UD) and uroguanylin (UGN) have been implicated in the regulation of salt and water homeostasis, particularly in the balance handling of salt intake. In this sense, the aim of the present work was to study the main effects of these peptides in kidneys from animals subjected to high NaCl (2%) intake, during 10 days in metabolic cages. The control group received only normal water, whereas the treated group drank 2% solution of NaCl (NaCl 2%). In addition, we studied effect of subthreshold UD (0.14 nM) and UGN (0.06 μM) doses in NaCl 2% after a 30-min control period. Kidney perfusion was performed with Krebs-Henseleit containing 6 g% bovine albumin previously dialyzed. The effects of UD (0.14 nM) promoted reduction of PP, RVR, and UF in the NaCl 2% group. We also observed an increase in %TNa + and %TCl -. The main effects of UGN in NaCl 2% were increase in PP, UF, and GFR, followed by a reduction in %TNa + and %TCl -. After an increased intake of salt, physiological pathways are activated and regulated in order to eliminate excess sodium. In this study, we observed that in a subthreshold dose, UD does not promotes natriuresis and diuresis, suggesting that UGN is an important hormone in inducing salt excretion in a chronic salt overload. Therefore, the effects herein described may play a contributory role in the regulation of kidney function after ingestion of salty meals.
dc.description.firstpage152
dc.description.issuenumber2
dc.description.lastpage159
dc.description.volume50
dc.identifier.doi10.1055/s-0043-120669
dc.identifier.issn1439-4286
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/35565
dc.relation.ispartofHormone and Metabolic Research
dc.rightsAcesso Restrito
dc.subject.otherlanguagenatriuresis
dc.subject.otherlanguageurodilatin
dc.subject.otherlanguageuroguanylin
dc.titleHigh Salt Intake Promotes Different Responses to Urodilatin and Uroguanylin in the Isolated Rat Kidney
dc.typeArtigo
local.scopus.citations0
local.scopus.eid2-s2.0-85038124820
local.scopus.subjectAnimals
local.scopus.subjectAtrial Natriuretic Factor
local.scopus.subjectGlomerular Filtration Rate
local.scopus.subjectKidney
local.scopus.subjectNatriuretic Peptides
local.scopus.subjectPeptide Fragments
local.scopus.subjectPerfusion
local.scopus.subjectPressure
local.scopus.subjectRats, Inbred WKY
local.scopus.subjectSodium Chloride, Dietary
local.scopus.subjectUrination
local.scopus.subjectVascular Resistance
local.scopus.updated2024-05-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85038124820&origin=inward
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