Post-weaning exposure to high-fat diet induces kidney lipid accumulation and function impairment in adult rats

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dc.contributor.authorMuller C.R.
dc.contributor.authorLeite A.P.O.
dc.contributor.authorYokota R.
dc.contributor.authorPereira R.O.
dc.contributor.authorAmerico A.L.V.
dc.contributor.authorNascimento N.R.F.
dc.contributor.authorEvangelista F.S.
dc.contributor.authorFarah V.
dc.contributor.authorFonteles M.C.
dc.contributor.authorFiorino P.
dc.date.accessioned2024-03-12T23:53:13Z
dc.date.available2024-03-12T23:53:13Z
dc.date.issued2019
dc.description.abstract© 2019 Muller, Leite, Yokota, Pereira, Americo, Nascimento, Evangelista, Farah, Fonteles and Fiorino.Aim: We investigated the kidney morphofunctional consequences of high-fat diet intake since post-weaning in adult rats. Main Methods: Male Wistar rats were divided into two groups: ND (normal diet; n = 10) and HD (high-fat diet; n = 10). The high-fat diet was introduced post-weaned and animals were followed for 8 weeks. Key Findings: HD group did not change body weight gain even though food consumption has decreased with no changes in caloric consumption. The HD group showed glucose intolerance and insulin resistance. The glomerular filtration rate (GFR) was decreased in vivo (ND: 2.8 ± 1.01; HD: 1.1 ± 0.14 ml/min) and in the isolated perfusion method (34% of decrease). Renal histological analysis showed a retraction in glomeruli and an increase in kidney lipid deposition (ND: 1.5 ± 0.17 HD: 5.9 ± 0.06%). Furthermore, the high-fat diet consumption increased the pro-inflammatory cytokines IL-6 (ND: 1,276 ± 203; HD: 1,982 ± 47 pg/mL/mg) and IL-1b (ND: 97 ± 12 HD: 133 ± 5 pg/mL/mg) without changing anti-inflammatory cytokine IL-10. Significance: Our study provides evidence that high-fat diet consumption leads to renal lipid accumulation, increases inflammatory cytokines, induces glomeruli retraction, and renal dysfunction. These damages observed in the kidney could be associated with an increased risk to advanced CKD in adulthood suggesting that reduction of high-fat ingestion during an early period of life can prevent metabolic disturbances and renal lipotoxicity.
dc.description.volume6
dc.identifier.doi10.3389/fnut.2019.00060
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/35270
dc.relation.ispartofFrontiers in Nutrition
dc.rightsAcesso Aberto
dc.subject.otherlanguageHigh-fat diet
dc.subject.otherlanguageInflammation
dc.subject.otherlanguageKidney lipid deposition
dc.subject.otherlanguageLipotoxicity
dc.subject.otherlanguagePost-weaning
dc.titlePost-weaning exposure to high-fat diet induces kidney lipid accumulation and function impairment in adult rats
dc.typeArtigo
local.scopus.citations27
local.scopus.eid2-s2.0-85067817576
local.scopus.updated2024-05-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85067817576&origin=inward
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