Adrenergic receptor β3 is involved in the memory consolidation process in mice

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dc.contributor.authorSouza-Braga P.
dc.contributor.authorLorena F.B.
dc.contributor.authorNascimento B.P.P.
dc.contributor.authorMarcelino C.P.
dc.contributor.authorRavache T.T.
dc.contributor.authorRicci E.
dc.contributor.authorBernardi M.M.
dc.contributor.authorRibeiro M.O.
dc.date.accessioned2024-03-12T23:59:13Z
dc.date.available2024-03-12T23:59:13Z
dc.date.issued2018
dc.description.abstract© 2018, Associacao Brasileira de Divulgacao Cientifica. All rights reserved.Attention and emotion have a positive impact on memory formation, which is related to the activation of the noradrenergic system in the brain. The hippocampus and amygdala are fundamental structures in memory acquisition, which is modulated by noradrenaline through the noradrenergic receptors. Pharmacological studies suggest that memory acquisition depends on the action of both the β3 (β3-AR) and β2 (β2-AR) receptor subtypes. However, the use of animal models with specific knockout for the β3-AR receptor only (β3-ARKO) allows researchers to more accurately assess its role in memory formation processes. In the present study, we evaluated short-and long-term memory acquisition capacity in β3-ARKO mice and wild-type mice at approximately 60 days of age. The animals were submitted to the open field test, the elevated plus maze, object recognition, and social preference. The results showed that the absence of the β3-AR receptor caused no impairment in locomotion and did not cause anxious behavior, but it caused significant impairment of short-and long-term memory compared to wild-type animals. We also evaluated the expression of genes involved in memory consolidation. The mRNA levels for GLUT3, a glucose transporter expressed in the central nervous system, were significantly reduced in the amygdala, but not in the hippocampus of the β3-ARKO animals. Our results showed that β3-AR was involved in the process of acquisition of declarative memory, and its action may be due to the facilitation of glucose absorption in the amygdala.
dc.description.issuenumber10
dc.description.volume51
dc.identifier.doi10.1590/1414-431X20187564
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/35607
dc.relation.ispartofBrazilian Journal of Medical and Biological Research
dc.rightsAcesso Aberto
dc.subject.otherlanguageAdrenergic receptors
dc.subject.otherlanguageGLUT3
dc.subject.otherlanguageMemory
dc.subject.otherlanguageβ3-AR
dc.titleAdrenergic receptor β3 is involved in the memory consolidation process in mice
dc.typeArtigo
local.scopus.citations7
local.scopus.eid2-s2.0-85052235356
local.scopus.subjectAnimals
local.scopus.subjectAvoidance Learning
local.scopus.subjectGene Expression Regulation
local.scopus.subjectMale
local.scopus.subjectMaze Learning
local.scopus.subjectMemory Consolidation
local.scopus.subjectMice
local.scopus.subjectReceptors, Adrenergic, beta-3
local.scopus.subjectRNA, Messenger
local.scopus.subjectSignal Transduction
local.scopus.updated2024-05-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85052235356&origin=inward
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