Sudden unexpected death in epilepsy: From the lab to the clinic setting

Terra V.C.; Cysneiros R.; Cavalheiro E.A.; Scorza F.A.

Sudden unexpected death in epilepsy: From the lab to the clinic setting

Tipo

Artigo de revisão

Data de publicação

2013

Periódico

Epilepsy and Behavior

Citações (Scopus)

42

Autores

Terra V.C.
Cysneiros R.
Cavalheiro E.A.
Scorza F.A.

Resumo

Sudden unexpected death in epilepsy (SUDEP) is defined as sudden, unexpected, witnessed or unwitnessed, non-traumatic, and non-drowning death in a patient with epilepsy. Sudden unexpected death in epilepsy is probably the most common cause of epilepsy-related deaths. Many predisposing and initiating factors may coexist and contribute to SUDEP, but the mechanisms are poorly understood. Cardiac and respiratory deregulation seems to have a major role in SUDEP. Here, we review several advances in understanding the mechanisms involved in SUDEP.This article is part of a Special Issue entitled "The Future of Translational Epilepsy Research". © 2012 Elsevier Inc.