Mannose binding lectin deposition in skin of lupus erythematosus patients: A case series

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dc.contributor.authorWallim L.R.
dc.contributor.authorNisihara R.
dc.contributor.authorSkare T.
dc.contributor.authorMocelin V.
dc.contributor.authorMessias-Reason I.J.
dc.date.accessioned2024-03-13T01:02:26Z
dc.date.available2024-03-13T01:02:26Z
dc.date.issued2014
dc.description.abstractIntroduction: Mannose binding lectin (MBL) has been linked to predisposition to systemic lupus erythematosus (SLE) and to disease activity. Some studies found deposits of MBL in glomerular tissue of patients with lupus nephritis. There is no research about the deposition of MBL in skin. Materials and methods: Skin biopsies from lesional and non lesional skin of 4 discoid lupus erythematosus (DLE) and 10 SLE patients were submitted to immunofluorescence staining for IgG, IgA, IgM, C3, C4, C1q, C5b-9 and MBL. Charts were reviewed for demographic, clinical and serological data. Patients with SLE had disease activity measured by SLEDAI. Results: MBL was found only in SLE lesional skin and its presence showed an association trend towards higher disease activity. Deposition of C5b-9 occurred in vessels only in patients with SLE (70%) and in the two patients with kidney involvement. Conclusions: MBL deposition was found in the lesional skin of SLE patients but not in SLE non lesional skin nor in DLE patients, and it seems to be less frequent and less strong than observed in the kidneys biopsies, suggesting that the complement participation in the pathophysiology of SLE process may not be the same in these two clinical manifestations. © 2014 American Society for Histocompatibility and Immunogenetics.
dc.description.firstpage629
dc.description.issuenumber7
dc.description.lastpage632
dc.description.volume75
dc.identifier.doi10.1016/j.humimm.2014.04.015
dc.identifier.issn1879-1166
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/36491
dc.relation.ispartofHuman Immunology
dc.rightsAcesso Restrito
dc.subject.otherlanguageBiopsy
dc.subject.otherlanguageLupus
dc.subject.otherlanguageMBL
dc.subject.otherlanguageSkin
dc.titleMannose binding lectin deposition in skin of lupus erythematosus patients: A case series
dc.typeArtigo
local.scopus.citations8
local.scopus.eid2-s2.0-84902260126
local.scopus.subjectAdult
local.scopus.subjectComplement C1q
local.scopus.subjectComplement C3
local.scopus.subjectComplement C4
local.scopus.subjectComplement Membrane Attack Complex
local.scopus.subjectFemale
local.scopus.subjectGene Expression
local.scopus.subjectHumans
local.scopus.subjectImmunoglobulins
local.scopus.subjectLupus Erythematosus, Discoid
local.scopus.subjectLupus Erythematosus, Systemic
local.scopus.subjectMale
local.scopus.subjectMannose-Binding Lectin
local.scopus.subjectMiddle Aged
local.scopus.subjectSeverity of Illness Index
local.scopus.subjectSkin
local.scopus.updated2024-05-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84902260126&origin=inward
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