Efeito da administração de ácido valpróico no comportamento de brincar na prole de ratos: um modelo animal para autismo
Tipo
Dissertação
Data de publicação
2006-09-12
Periódico
Citações (Scopus)
Autores
Campos, Maria Lucila Ribeiro
Orientador
Mercadante, Marcos Tomanik
Título da Revista
ISSN da Revista
Título de Volume
Membros da banca
Chiavegatto, Silvana
Programa
Distúrbios do Desenvolvimento
Resumo
Autism is a pervasive development disorder characterized by impairment in three areas: sociability, communication and repetitive behaviors, having a multicausal etiology, including genetic and environmental agents. In the late years, the seizures treatment with VPA during pregnancy has been related to higher occurrence of autism. In order to investigate the possible causes of autism, animal models had been used with expressive results. This study explores the impact in the sociability development in animals exposed to VPA during gestation. Pregnant rats were treated VPA in the 9th day of gestation and social behavior of the offspring were analyzed. The results showed a significant impairment in several forms of social behavior. Recent publications show abnormal serotonin neuron migration associated with VPA which might be underlying the mechanisms of these behaviors.
Descrição
Palavras-chave
ácido valpróico , autismo , sociabilidade , autism , sociability
Assuntos Scopus
Citação
CAMPOS, Maria Lucila Ribeiro. Efeito da administração de ácido valpróico no comportamento de brincar na prole de ratos: um modelo animal para autismo. 2006. 56 f. Dissertação (Mestrado em Psicologia) - Universidade Presbiteriana Mackenzie, São Paulo, 2006.