Liberação de princípios ativos revestidos com biosistemas poliméricos
Tipo
Dissertação
Data de publicação
2018-08-10
Periódico
Citações (Scopus)
Autores
Monção, Camila Paraiso
Orientador
Miranda, Leila Figueiredo de
Título da Revista
ISSN da Revista
Título de Volume
Membros da banca
Munhoz Junior, Antônio Hortêncio
Silva, Leonardo Gondim de Andrade e
Silva, Leonardo Gondim de Andrade e
Programa
Engenharia de Materiais
Resumo
In this work the main characteristics, applications, potentialities and limitations of the controlled release systems were studied, as well as the mechanisms that directly influenced the release kinetics of the active agent. Micro and nanostructured systems have great potential for the controlled release and encapsulation of bioactive molecules. The various biodegradable polymer systems represent a new strategy for the delivery of active ingredients. A controlled release system enables the drug concentration profile to remain constant within the therapeutic range thereby promoting increased therapeutic index and immune response to the patient and avoiding adverse side effects when compared to conventional methods of administration. In this work were obtained membranes formed by polymeric biosystems for application in controlled release of drugs and other assets. Four release systems were obtained: beeswax / protein / lecithin; beeswax / protein / alginate / lecithin and beeswax / alginate / chitosan / lecithin by methods of complex coacervation and spray drying. The results show that the most effective system was bee / protein / alginate / lecithin.
Descrição
Palavras-chave
liberação controlada , encapsulação de moléculas bioativas , coacervação complexa , spray drying
Assuntos Scopus
Citação
MONÇÃO, Camila Paraiso. Liberação de princípios ativos revestidos com biosistemas poliméricos. 2018. 68 f. Dissertação( Engenharia de Materiais) - Universidade Presbiteriana Mackenzie, São Paulo.